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KMID : 0363620160370020076
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Journal of Korean Oriental Medicine
2016 Volume.37 No. 2 p.76 ~ p.84
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Rh2-enriched Korean Ginseng Ameliorates Chronic Fatigue in a Forced Exercise mouse model
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Kim Won-Yong
Lee Jin-Seok
Yoon Hwa-Seung
Son Chang-Gue
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Abstract
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Objectives: We evaluated the anti-fatigue effects of Rh2-enriched Korean ginseng (Ginseng Rh2+) using a forced exercise-induced chronic fatigue mouse model.
Methods: ICR male mice were subjected to running wheel for 1 h, 5 days/week during 4 weeks, and running velocity was gradually increased. Each running session was followed by oral administration of distilled water, Ginseng Rh2+ (150 or 300 mg/kg), or N-acetyl-L-cysteine (NAC, 100 mg/kg) 1 h later. The exercise tolerance and forced swimming test were performed to evaluate the fatigue condition.
Results: Chronic forced exercise reduced the physical activity, as evidenced by the behavioral tests, which were notably ameliorated by Ginseng Rh2+ treatment. Ginseng Rh2+ treatment also attenuated the alterations of energy metabolism and oxidative stress in skeletal muscle tissues and/or sera, including malondialdehyde (MDA), lactate concentration and its related factors (lactate dehydrogenase, blood urea nitrogen, and glucose levels).
Conclusion: These findings strongly suggest that Ginseng Rh2+ exerts a potent anti-fatigue effect through modulation of energy metabolism and oxidative response.
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KEYWORD
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Chronic fatigue, Oxidative stress, Lactate, Ginseng Rh2+
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